The Approval Process Moves Ahead For Moderna And J&J Boosters

Vaccine advisers will be meeting the US Food and Drug Administration on Thursday and Friday of this week. The meeting will be to tackle the next round of questions about the booster doses. 

The committee will be discussing the data on mix-and-matching the booster doses for Covid-19. Moderna’s application for its booster dose will be discussed in Thursday’s meeting.

The Approval Process Moves Ahead For Moderna And J&J Boosters

Moderna administers its Covid-19 vaccine in two shots, and a booster dose will add on as the third vaccine shot.

The meeting on Friday will be focused on Johnson & Johnson application for its booster shots. Johnson & Johnson Administers its Covid-19 vaccine as a single shot, and the booster shot will add on a second shot.

The Approval Process Moves Ahead For Moderna And J&J Boosters

Once the committee is sure about their decision regarding booster doses by the two pharma, they will then be discussing the pros and cons of mixing and matching the booster doses. The efficacy and safety of mix-and-match booster doses will be decided by the FDA’s Vaccines and Related Biological Products Advisory Committee, the VRBPAC.

The question about mixing and matching boosters is prominently under discussion among citizens as well as experts. The discussion got hype when the FDA approved applications for booster doses by different vaccine manufacturers. The answer is much awaited about whether it is safe to do so and if it is even desirable to mix and match Covid-19 booster shots.

Researches are already under process to evaluate the various possibilities of mixing and matching the booster shots. 

Dr. Angela Branche, assistant professor at the University of Rochester School of Medicine, is working on some clinical trials regarding mixing Covid-19 booster shots and checking for their safety and effects.

She said, “We first worked upon people who have previously received their Covid-19 shots either by Johnson & Johnson, Moderna, and Pfizer. We gave them an additional dose of the Moderna Covid-19 vaccine. The trial also studied the effect of Pfizer’s and Johnson & Johnson’s booster shots on the volunteers. 

The National Institute of Health on Wednesday stated that mixing and matching boosters create a strong immune response. The results were obtained after the study was conducted on about 40 people. However, the study has not been peer-reviewed and published so far.

The participants who received their initial vaccination from Johnson & Johnson were given boosters from Pfizer or Moderna. Such mixing showed the production of stronger antibody responses.

The participants who received their initial vaccination from Pfizer or Moderna seemed to produce a comparable antibody response with any booster.

The study, although, shows that receiving booster shots different from your initial vaccination is completely safe. The side effects recorded after the administration of the booster shot were similar to those experienced past the initial vaccination. The side effects participants reported were: pain at the injection site, nausea, headache, muscle pain, tiredness none of the side effects were serious as to call booster mix match unsafe. These were generally reported mostly after one to three days from the booster. 

The studies assure that approving booster doses will assuredly boost the immune response among citizens.

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