Recent research has found that fish oil supplements may assist those with depression. Our study used a combo of lab and outpatient studies to discover the ways in which omega-3 fat radicals contribute to anti-inflammatory actions that alleviate depression.
Fish Oil Supplements May Help With Depression, According To Some Research
In the past, omega-3 polyunsaturated lipids have been known to offer anti-depressant & anti-inflammatory actions, but no one was able to explain how that occurred.
Dr. Borsini was quoted in a university press release as, “This work has illuminated the cellular underpinnings behind this link, which may guide the discovery of new therapies utilizing omega-3 PUFA.”
Until now, previous research has revealed that individuals with serious distress had an increase in inflammation, but no therapies for depression with established anti-inflammatory benefits exist. This new trial, which involved 22 persons with serious depression, covered the patient group.
3 grammes of eicosapentaenoic acid (EPA) or 1.4 grammes of docosahexaenoic acid (DHA). EPA & DHA are omega-3 PUFAs, also known as eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), are present in fish oil.
To find out if sufferers’ blood had traces of EPA and DHA byproducts pre and post-therapy, we evaluated EPA and DHA levels in the patients’ blood. We also measured the patients’ depression pre and post-treatment.
The EPA group saw a large reduction in symptoms, with a mean 64% decrease in symptoms, whereas the DHA group experienced a large increase in symptoms, with an average 71% increase in symptoms. There is no correlation between the two. The results were released in the journal Molecular Psychiatry on June 16th.
This report found that people won’t obtain the amounts of EPA & DHA seen in fatty fish through diet alone. “This research has revealed critical information that will help inform future clinical studies on therapies that target omega-3 fatty acids,” stated senior paper researcher Carmen Pariante, a researcher of biological psychiatry.
Although this research shows that boosting omega-3 fatty molecules in our foods or via the use of nutritional supplements does not help to reduce inflammation or sadness, she emphasized the importance of pointing this out. More study and clinical trials are required to completely understand how the mechanisms of sadness and omega-3 PUFA function, and how they influence future therapy approaches.
The goal of this review was to assess clinical data and speculate on the antidepressant mechanisms associated with PUFA. The trials discovered that fish oil intake is more effective than placebo in treating depression, and evidence shows that the most favorable results occur when fish oil is administered alongside traditional antidepressant therapy. Nevertheless, clinical studies differ in concept and methodology making direct comparisons impossible.
It is also important to remember that the three primary concepts relevant to the mode of action of PUFAs are mentioned in this review. The compound has an anti-inflammatory effect Conversely, direct membrane alteration is referred to as 2) immediate membrane alteration, while indirectly membrane alteration is known as 3) intermediate membrane mutation via direct alteration of signaling proteins.
There is data supporting all 3 of these theories, and we, therefore, conclude that all three must be occurring simultaneously. Luckily, in neuroscience, technique improvement is growing rapidly, providing hope that solutions may be found shortly.